Kali, invoking the name of God, is the most effective way to purify and build a relationship with God.
“The holy name, the holy name, the holy name of the Lord is the path of spiritual development for those who live in the age of Kali. Not any other way, not any other way, not any other way.
(Chaitanya Charitamrita adi lila 7.76)
Kali-yuga is an ocean of evils, but besides them there is another great virtue: simply by chanting the Hare Krsna maha-mantra one can become liberated from material bondage and enter into the transcendental world.
(Srimad Bhagavatam 12.3.51)